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first_imgThe University’s website states: “The purpose of the Agreement is not to prescribe an additional code of discipline; it is to support community safety and well-being. It is an affirmation of shared values – community, consideration for others, patience and tolerance, and inclusion.” The agreement explicitly commits students to follow college/University guidelines on how to interact with and share communal spaces with members of their household. If they live in a private household, they commit to following the relevant Government/Public Health England guidance. Additionally, students are expected to request a test via the University’s testing service if they experience COVID-like symptoms and to notify their College and Department. The University has announced that all students will be asked to sign a COVID-19 Student Responsibility Agreement at the start of the 2020/21 academic year. The agreement supplements students’ existing responsibilities under University and college student contracts. Students are encouraged to speak to a relevant welfare contact or Departmental Administrator should they believe that someone’s conduct is “persistently and unreasonably creating serious risk.” Possible consequences that the University has committed to range from a discussion with individuals about their behaviour to disciplinary action. Students will be expected to participate fully in any contact tracing if they are requested to do so and will be held responsible for ensuring that their guests adhere to the same standards of behaviour in University, college, or other spaces.center_img However, students are reminded that circumstances will be different and “any response must be appropriate and proportionate.” Regarding the wearing of masks, the University’s website urges students to “remain mindful of possible valid reasons for not wearing a mask, and not challenge an individual about this, no matter how tactfully.” Each student is expected to make eight commitments about their behaviour by signing the agreement. These include “abiding by all national public health regulations brought in to stop the spread of COVID-19,” as well as “the University and/or colleges’ specific guidance on health measures, together with local public health guidance as relevant.” The full agreement and FAQs can be found here.last_img read more


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first_img Critical step found in DNA repair, cellular aging Millions of self-assembling DNA propellers can fit into just one microscope slide, which means the team can study hundreds or even thousands of them at once, using just one camera attached to one microscope. That way, they can compare and contrast how individual motors perform their work.“There are no two enzymes that are identical,” Kosuri said. “It’s like a zoo.”One motor protein might leap ahead while another momentarily scrambles backwards. Yet another might pause on one base for longer than any other. The team doesn’t yet know exactly why they move like they do. Armed with ORBIT, they soon might.ORBIT could also inspire new nanotechnology designs powered with biological energy sources such as ATP. “What we’ve made is a hybrid nanomachine that uses both designed components and natural biological motors,” Kosuri said. One day, such hybrid technology could be the literal foundation for biologically-inspired robots. David Quammen and Carl Zimmer discuss how tangled the tree of life can be Mining the mysteries of DNA Experiments in mice suggest way to thwart DNA damage from aging, radiation center_img For decades, researchers have chased ways to study how biological machines power living things. Every mechanical movement — from contracting a muscle to replicating DNA — relies on energy-fueled molecular motors that take tiny, near-undetectable steps. Trying to see these movements is like trying to watch a soccer game on the moon from Earth.Now, in a recent study published in Nature, a team of researchers including Xiaowei Zhuang, the David B. Arnold Jr. Professor of Science at Harvard University and a Howard Hughes Medical Institute Investigator, Pallav Kosuri, a postdoctoral scholar in chemistry and chemical biology in the Zhuang lab, and Benjamin Altheimer, a Ph.D. student in the Graduate School of Arts and Sciences, captured the first recorded rotational steps of a molecular motor as it moved from one DNA base pair to another.In collaboration with Peng Yin, a professor at the Wyss Institute and Harvard Medical School, and his graduate student Mingjie Dai, the team combined DNA origami with high-precision single-molecule tracking, creating a new technique called ORBIT — origami-rotor-based imaging and tracking — to look at molecular machines in motion.In humans, some molecular motors march straight across muscle cells, causing them to contract. Others repair, replicate, or transcribe DNA: These DNA-interacting motors can grab onto a double-stranded helix and climb from one base to the next, like walking up a spiral staircase. To see these mini machines in motion, the team wanted to take advantage of the twisting movement. First, they glued the DNA-interacting motor to a rigid support. Once pinned, the motor had to rotate the helix to get from one base to the next. So, if they could measure how the helix rotated, they could determine how the motor moved.But researchers face a problem: Every time one motor moved across one base pair, the rotation shifted the DNA by a fraction of a nanometer. That shift was too small to monitor with even the most advanced light microscopes.Two pens lying in the shape of helicopter propellers sparked the idea for a solution: A propeller fastened to the spinning DNA would move at the same speed as the helix and, therefore, the molecular motor. If they could build a DNA helicopter, just large enough to allow the swinging rotor blades to be visualized, they could capture the motor’s elusive movement on camera.To build molecule-sized propellers, Kosuri, Altheimer, and Zhuang decided to use DNA origami. Used to create art, deliver drugs to cells, study the immune system, and more, DNA origami involves manipulating strands to bind into beautiful, complicated shapes outside the traditional double helix.“If you have two complementary strands of DNA, they zip up,” Kosuri said. “That’s what they do.” When one strand is altered to complement a strand in a different helix, they can find each other and zip up instead, weaving new structures.,To construct their origami propellers, the team turned to Yin, a pioneer of origami technology. With his and Dai’s guidance, the team wove almost 200 individual pieces of DNA snippets into a propeller-like shape 160 nanometers long. Then they attached propellers to a regular double helix and fed the other end to RecBCD, a molecular motor that unzips DNA. When the motor got to work, it spun the DNA, twisting the propeller like a corkscrew.“No one had seen this protein actually rotate the DNA because it moves super-fast,” Kosuri said.The motor can move across hundreds of bases in less than a second. But with their origami propellers and a high-speed camera running at a thousand frames per second, the team could finally record the motor’s fast rotational movements.“So many critical processes in the body involve interactions between proteins and DNA,” said Altheimer. Understanding how these proteins work — or fail to — could help answer fundamental biological questions about human health and disease.The team started to explore other types of DNA motors. One, RNA polymerase, moves along DNA to read and transcribe the genetic code into RNA. Inspired by previous research, the team theorized this motor might rotate DNA in 35-degree steps, corresponding to the angle between two neighboring nucleotide bases.ORBIT proved them right. “For the first time, we’ve been able to see the single-base-pair rotations that underlie DNA transcription,” Kosuri said. Those rotational steps are, as predicted, around 35 degrees. Related The Daily Gazette Sign up for daily emails to get the latest Harvard news.last_img read more


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first_imgSign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York The Suffolk County Welfare to Work Commission released an in-depth analysis Monday that found many eastern Long Island families need help providing quality preschool programs for their children.The report recommended creating a Suffolk County Child Care and Early Learning Commission to help coordinate services, urging New York State to change the formula that underfunds Suffolk County’s working poor, increasing the allocation of county funds for child care to stimulus-era amounts and establishing a Suffolk County Children’s Trust Fund to alleviate some of the unmet needs of preschool-age children. They estimated cost is about $5 million—far higher than the $580,000 allocated in the state budget for such programs.“Adequate funding has not kept up with the rhetoric,” said Richard Koubek, who authored the report and chairs the commission that was designed to aid politicians in making policy decisions.Koubek cited the 2013 State of the Union Address in which President Barack Obama called for expanded preschool educational opportunities as a starting point for the conversation.The report, titled “Who’s Minding the Kids? Meeting Challenges and Creating Opportunities for Quality Child Care and Early Learning in Suffolk County,” included testimony and information gleaned from two public hearings, 11 focus groups and a survey that polled more than 100 parents. Some of the Island’s leading child-care and early-learning experts weigh in, citing extensive research pointing to the fact that extensive brain growth occurs between ages birth to 5 years old, yet 95 percent of education funding is aimed at students 5 and older.The lack of adequate programs also presents a financial conundrum to the underprivileged. On LI, which has the sixth-highest cost of living in the nation., most mothers need to hold a job outside of the home to make ends meet. Yet, without enough child care programs to serve them, families are torn between non-accredited, unsafe child-care conditions, or sacrificing employment.The commission illustrated the point with Keesha Bailey, a working mother of four. When she was pregnant with her fourth child, her hourly wage was raised 75 cents. This brought her $8 above the maximum to qualify her for subsidized child care for her two youngest children. When she lost a challenge of that determination, she was charged $17,000 for child care used while she attended the hearing.She’s currently paying off her debt in $50 weekly increments. She estimates that it will take nine-and-a-half years to fully repay it, long after her last child has graduated pre-K.The commission found that investment in comprehensive early education programs will pay off in the long term, resulting in students who are more “college and career ready,” require less special-education funding and will be more likely to contribute positively and financially to LI in adulthood. The commission said its recommendations would help Bailey’s children and those like them by expanding child-care subsidy eligibility for working-poor families.“As a county,” said Dana Friedman, president and founder of the Early Years Institute, “we can do better.”last_img read more


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first_imgAn Otsego County jury convicted Truitt to first-degree murder, two counts of second-degree murder and arson. Truitt’s brother, Terrance was originally arrested for the crime in January of 2019. After further investigation police revealed that it was Gabriel who committed the crime. Gabriel was arrested in April. Truitt set the fire at 5 Walling Avenue after getting into a fight with his on again off again girlfriend, Heather Engler. Heller died after trying to go into the home to save his fiancée and his four nephews from the fire on December 29, 2018. Heller was 38 years-old when he died.center_img COOPERSTOWN (WBNG/WKTV)- On Thursday, Gabriel Truitt was found guilty of committing arson and the murder of former Oneonta firefighter John Heller. Truitt’s sentencing will take place April 3 and he faces up to life in prison with parole.last_img read more


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first_imgAustralia reported a jump in coronavirus cases on Tuesday that was almost entirely due to passengers who disembarked a cruise ship in Sydney several days ago, prompting widespread criticism of the official response to the pandemic.The ship, Carnival Corp’s Ruby Princess, became the country’s largest source of coronavirus infections as one of its passengers also became the eighth fatality nationally.In a chain of events described by New South Wales state Police Minister David Elliott as a “monumental stuff-up”, about 2,700 passengers were allowed to leave the ship when it docked in Sydney on March 19. “We are ramping up our compliance,” she told reporters in Sydney. “There are harsh penalties and we’ll enforce that. We have to take this seriously.”Carnival Corp said it was “profoundly sorry” to learn that the Princess Ruby passenger, a woman in her 70s, had died.”This sad development underlines the challenges we are all facing as a community in the battle against the impact of COVID-19,” the company said in an emailed statement.Authorities had initially classified the ship as low risk because it was returning from an 11-day round trip to New Zealand, despite around a dozen passengers showing signs of ill health. About 60% of the passengers were Australian, and 20% were from the United States, ship records showed.The ship had been rated “medium risk” after its previous cruise, again to New Zealand. On that trip, some 158 passengers registered high temperatures. Nine were tested on arrival in Sydney on March 8 and were allowed to disembark before passengers for the most recent cruise embarked later the same day. A couple from the prior cruise who flew on to Darwin later tested positive for COVID-19.As the Princess Ruby case numbers rose, officials denied passengers on the Swiss-owned MSC Magnifica cruise permission to disembark on the country’s west coast, despite MSC Cruises assurances that none showed any signs of a respiratory or flu-like illness.Unemployment and confusionAustralia’s move to a stricter lockdown was beginning to show visible signs of social stress with long queues forming outside offices of the main welfare agency across the country.Westpac economists said that the extraordinary measures in place to counter the spread of the disease would push the unemployment rate above 11%, which would be the highest since the country was last in recession in the early 1990s.For many, there has been anger over mixed messages from officials in Australia’s system of federal and state governments, which are separately responsible for regulating different services.The operation of schools has been a flashpoint, with Prime Minister Scott Morrison advising they remained open and safe for students to attend, while some state leaders urged parents to keep their children home.”It is as clear as mud and no wonder parents are confused out there,” Anthony Albanese, the leader of the federal opposition party, told ABC Radio.Morrison was due to meet with the national cabinet formed to deal with the crisis, comprising state and federal political and health officials, later on Tuesday to discuss the next steps. Topics :center_img By Tuesday, around 130 of those passengers had tested positive and officials were frantically hunting down other travellers to test them and track their movements.Australia stepped closer to a full lockdown on Tuesday, with authorities warning of harsher penalties for anybody violating self-isolation orders as they began to worry that hospitals were starting to feel the strain.With 1,984 cases, Australia has registered significantly lower rates of coronavirus compared to elsewhere in the world, but the infection rate has quickened in recent days and NSW Premier Gladys Berejiklian said it was now at a “critical stage.”While schools officially remained open in most of the country, parents were strongly advised to keep their children home, as all other non-essential services, including cinemas, pubs and houses of worship, were closed for the first full day.last_img read more


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first_imgBut their favourite feature is the tropical gardens which they have developed over the years.“We are both keen gardeners and that’s probably what has kept us here so long,” he said.The property is set to hit the market through Mark Saveall of McGrath Estate Agents.“I don’t think there is another house like it on the Gold Coast within 5km of the ocean,” he said.“These types of houses are a dying breed unfortunately.“But they are the perfect design for our climate – they are the original open-plan home.” Video Player is loading.Play VideoPlayNext playlist itemMuteCurrent Time 0:00/Duration 0:58Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:58 Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedCaptionscaptions settings, opens captions settings dialogcaptions off, selectedQuality Levels720p720pHD432p432p216p216p180p180pAutoA, selectedAudio Tracken (Main), selectedFullscreenThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.This is a modal window. This modal can be closed by pressing the Escape key or activating the close button.Close Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button.PlayMuteCurrent Time 0:00/Duration 0:00Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:00 Playback Rate1xFullscreenHow much do I need to retire?00:58 MORE NEWS: Renovated castle has ‘secret’ room Pam and Lloyd Nugent are selling their property Two Views after having lived there for 25 years. Pic Tim Marsden“But I could always see it had potential to be a nice home.”Over the years the pair breathed new life into the house — they installed new kitchens, French doors and casement windows.More from news02:37International architect Desmond Brooks selling luxury beach villa13 hours ago02:37Gold Coast property: Sovereign Islands mega mansion hits market with $16m price tag2 days agoThe three-bedroom residence features a pool, fire pit, open plan kitchen, living and dining areas as well as an outdoor entertaining area.Mr Nugent said its location at 13 Ernest St initially sparked their interest.“For us it’s up on the hill and it’s an ideal spot,” he said.“It also gave us a project to work on.”MORE NEWS: Melbourne family will live like The Jetsons Pam and Lloyd Nugent are selling their property Two Views after having lived there for 25 years. Pic Tim MarsdenWIDE verandas decorated with fretwork, open-plan living areas, wooden floors and casement windows.The Gold Coast is not known for traditional Queenslander-style houses but Lloyd and Pam Nugent are hoping theirs will strike a chord with house hunters.The 100-year-old Queenslander in Labrador is up for sale at offers over $899,000.As well as a raft of traditional features from the early 1900s, the property comes with an extensive history. “The people who owned it originally could see the Hinterland and they could see the Broadwater so they called it Two Views,” Mr Nugent said.“When we bought it people used to say to us ‘you bought Two Views’ — it was talked about a lot in the area.”The pair, both retired, paid $150,000 for the property in 1996 but said it was in desperate need of a revamp.“It had been terribly neglected,” he said.last_img read more


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first_imgUnique Group has signed an agreement to acquire five unmanned surface vessels (USV) DriX units from French high-technology company iXblue.Unique Group’s new addition is designed for a wide range of tasks such as geophysical and hydrographic surveys, touchdown monitoring of pipelines, subsea positioning, and ROV/AUV tracking.The acquired units will be placed within Unique Group’s global rental pool and accessible to clients across the Middle East, Europe, South East Asia and the Americas.Harry Gandhi, CEO at Unique Group, said: “We’re extremely delighted to add DriX to our ever-expanding inventory of USVs. DriX has proven to be a real game changer in the offshore market and been used across many successful subsea positioning and bathymetry missions. We look forward to the prospect of further developing our partnership with iXblue in the future.”Sébastien Grall, head of iXblue Shipyard Division, stated: “Since its launch in the offshore and hydrographic markets, DriX has been met with incredible success and positive feedbacks. With outstanding seakeeping capabilities, the USV has set a new standard in the industry of surface drones. This agreement with Unique Group is another endorsement of the added value DriX brings to subsea operations and we now look forward to seeing the units in use across various industries for survey, offshore, marine sciences as well as hydrographic operations.”last_img read more


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first_img It is also being reported that Barcelona are also interested in signing the goalkeeper with the club also happy to do business with the La Liga giants instead. But Onana himself prefers a move to England rather than to Spain. And according to Daily Mail, Ajax custodian Onana has set his sights on a move to Premier League and London with both Chelsea and Tottenham Hotspur his preferred destinations. The 23-year-old Cameroon international could be worth around £40-50 million and has two years to run in his current contract with the Dutch Eredivisie club. Chelsea are currently undergoing a goalkeeping crisis with world record signing Kepa Arrizabalaga not impressing many including head coach Frank Lampard who dropped the Spaniard for their recent Premier League fixture against Leicester City. Promoted ContentWho Is The Most Powerful Woman On Earth?The Most Exciting Cities In The World To VisitBest & Worst Celebrity Endorsed Games Ever Made8 Superfoods For Growing Hair Back And Stimulating Its GrowthYou’ve Only Seen Such Colorful Hairdos In A Handful Of AnimeWhy Go Veg? 7 Reasons To Do This5 Of The World’s Most Unique Theme ParksHere Are The Top 10 Tiniest Mobile Phones On The Planet!Birds Enjoy Living In A Gallery Space Created For Them7 Truly Incredible Facts About Black Holes10 Hyper-Realistic 3D Street Art By Odeith5 Of The World’s Most Unique Theme Parks Loading… Read Also: Chelsea hand Lampard £150m summer transfer kitty Other sources also report that Onana has Chelsea as his most preferred destination. Spurs are also interested in a goalkeeper with current first-choice Hugo Lloris now 33 years of age. FacebookTwitterWhatsAppEmail分享 Highly-rated Ajax goalkeeper Andre Onana has reportedly expressed his interest in making a transfer move to the Premier League and specifically Chelsea.last_img read more


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first_imgRelatedPosts Tyson Fury to Anthony Joshua: Don’t risk fighting Usyk Anthony Joshua wants Tyson Fury, Wilder fight Joshua: Tyson Fury won’t distract me Wladimir Klitschko wants Anthony Joshua to become the world’s no 1 but admits he must face the Deontay Wilder-Tyson Fury winner to achieve that status. Joshua is set to make the next defence of his WBA ‘super’, IBF and WBO heavyweight titles against Kubrat Pulev in June, while Wilder puts his WBC belt at stake in a rematch with Fury in Las Vegas this weekend. Klitschko has been retired since 2017 after an epic Wembley defeat to Joshua and believes the fellow Olympic gold medallist has the necessary attributes to emerge as the sole heavyweight champion. Speaking at the Laureus World Sports Awards, Klitschko said: “I wish that’s going to be Joshua, because I think all around, he’s a superior athlete, Olympic champion, great guy for the sport and being an ambassador for the sport. I think he’s got it all. “Obviously, no-one is perfect. Always some stronger and weaker sides, but I think he has the potential to be that one and that’s what I wish actually. “How these cards are going to be mixed up and eventually we will have and will see the guy from those three. Let’s just lean back, relax and observe.” The Ukrainian’s lengthy reign as a unified title holder was ended by a points loss to Fury in 2015 and Klitschko thinks the Brit must find a way to nullify Wilder’s power, if he is to become a two-time world champion. “Either Wilder is going to knock Fury out, or Fury is going to win on points,” said Klitschko. “That’s how I see it. It could go 50-50. There’s no particular advantage or disadvantage to any of those guys.”Tags: Deontay WilderTyson FuryWladimir Klitschkolast_img read more


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