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first_imgA new study led by Oxford Professor Daniel Freeman claims to have definitively shown that cannabis can cause short-term paranoia in “some people.”More importantly however, the study also identifies the ways in which our minds encourage paranoia. Professor Freeman, of University College, concluded that “paranoia is likely to occur when we are worried, think negatively about ourselves, and experience unsettling changes in our perceptions.”The study, published in the journal Schizophrenia Bulletin, is the first to determine the psychological factors that can result in feelings of paranoia in cannabis users, and confirms the findings of investigations dating back to the 1930s, as well as the widely-held suspicions of centuries of users.The research involved Freeman’s team tested the mental responses of 121 participants between the ages of 21 and 50, all of whom had taken cannabis at least once before and none of whom had any history  of mental illness or health condition, while they were placed in tests of “excessive suspiciousness.” These including real-life social situations, a virtual reality simulation, self-report questionnaires and clinical interviews.Two-thirds of the participants were injected with the main psychoactive ingredient in cannabis, THC (Δ9-tetrahydrocannabinol), while a third received a placebo. The dose of THC was equivalent to a strong joint, with the chemical having effect for 90 minutes.Half of the participants who took THC reported paranoid thoughts, compared to 30% of those who took the placebo.The drug also caused a range of other psychological effects in those who took it, ranging from anxiety, worry, lowered mood, and negative thoughts about the self, to various changes in perception such as sounds being louder than normal and colours brighter, thoughts echoing, altered perception of time, and poorer short-term memory.Commenting on the findings, Professor Freeman explained that “paranoia is likely to occur when we are worried, think negatively about ourselves, and experience unsettling changes in our perceptions.“Paranoia is excessive thinking that other people are trying to harm us. It’s very common because in our day-to-day lives we have to weigh up whether to trust or mistrust, and when we get it wrong – that’s paranoia. The study identifies a number of highly plausible ways in which our mind promotes paranoid fears.He continued, “The study provides a great deal more information about the immediate effects of cannabis, but it did not investigate clinically severe disorder. The results don’t necessarily have any implications for policing, the criminal justice system, or legislation. It tells us about the little discussed paranoid-type fears that run through the minds of so many people from time to time.“The implication is that reducing time spent ruminating, being more confident in ourselves, and not catastrophizing when unusual perceptual disturbances occur will in all likelihood lessen paranoia.”Meanwhile, a first year Jesus geographer agreed that the ill-effects of paranoia from cannabis can be lessened by a positive outlook, commenting that “being paranoid would be unpleasant if I wasn’t extremely comfortable on a sofa or sunbathing.”However, he also told Cherwell, “these findings have nevertheless seriously made me question the efficacy of bunning, especially since I hear that second year is really tough.”last_img read more


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first_imgBakery manufacturer Frank Roberts & Sons has posted a 9% increase in group operating profit, to £5.9m, for the full year to 1 September 2012.Sales revenue stood at £81.2m, up 3% on 2011 (£79.1m).The firm put the improved performance down primarily to strong bread volumes and increased sales of confectionery.“The result was achieved despite ongoing commodity inflation, intense competition within the bread market and poor weather during the summer, which had a direct effect on morning goods volumes,” said the firm.However in its latest accounts, filed at Companies House, the firm admitted to having reduced its employee numbers in a bid to streamline operations and  reduce its cost base. Its staff headcount dropped 7% from 2011 to 2012, from 898 to 839.The prior year also saw exceptional costs of £0.8m related to the acquisition of P&A Davies.The firm manufactures and distributes bread, morning goods, gluten-free products, pastry products and confectionery.last_img read more



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first_imgIn a study that seems to pivot on a paradox, scientists at Harvard-affiliated Dana-Farber Cancer Institute have used an immune system stimulant as an immune system suppressor to treat a common, often debilitating side effect of donor stem cell transplantation in cancer patients.  The effect, in some cases, was profound.The phase 1 study, published in the Dec. 1 issue of the New England Journal of Medicine, involved allogeneic (donor) stem cell transplant patients with chronic graft-versus-host disease (GVHD), a multisystem inflammatory condition that arises when donor immune system cells launch an attack on a patient’s own tissues, leading to varied symptoms such as skin rash and thickened or scarred skin, lung inflammation, or hepatitis, among others.  The patients received once-daily injections of interleukin-2 (IL-2), a drug traditionally used to spur an immune system attack, but which, at low doses, investigators had reason to believe, could have the opposite effect in this case: blunting a harmful activation of the immune system and subduing GVHD.After eight weeks on the regimen, 12 of 23 participants showed clear physical benefits, including softened skin and underlying tissue, reduced redness of skin, improved mobility and gait, improved liver function, and resolution of neuropathy, a degenerative nerve condition.  The responding patients who went on to receive longer-term daily IL-2 continued to show improvements, including alleviations of skin conditions that had previously been considered irreversible in chronic GVHD, while simultaneously reducing their other immune-suppressing medications.  In fact, four of 10 patients on longer-term IL-2 treatment have completely tapered off glucocorticoids (steroid hormones), and two of them have stopped all other immune suppression medications as well.  This group of patients has been able to reduce the use of glucocorticoids by an average of 60 percent.None of the patients in the trial had their chronic GVHD progress while taking IL-2 and none had a relapse of their original cancer.  None of the patients contracted opportunistic viral or fungal infections while on the IL-2 therapy, suggesting their immune systems remain functional.“More than half of patients who successfully undergo hematopoietic stem cell transplants [in which the blood-making tissue in the bone marrow is wiped out with chemotherapy and replaced with blood-forming stem cells from a donor] develop chronic GVHD,” says the study’s lead author, John Koreth of Dana-Farber.  “The conventional treatment, glucocorticoids, are limited in their effectiveness and can produce significant side effects.”He adds that the findings show that low-dose IL-2 is both safe for patients with active, chronic GVHD and it can produce powerful immunological effects — reversing, in some cases, some of the most severe symptoms of GVHD.  “This technique not only offers a new way of treating GVHD but possibly also of approaching a range of inflammatory conditions that result from an imbalance in the immune system,” says Koreth, who is an assistant professor at Harvard Medical School (HMS).“We had good reason to believe this low-dose approach would be safe, based on our previous experience,” Koreth says, “but the irony is that it represents a complete reversal of the rationale on which IL-2 therapy was originally based.”[youtube https://www.youtube.com/watch?v=/osGOhgtb6so%20]“This study demonstrates that daily injection of low-dose IL-2 is safe for patients with active, chronic GVHD and can restore the balance between pro- and anti-inflammatory immune system cells in their bodies.  It shows that, in some patients, this approach can reverse the most severe manifestations of the disease, while also allowing them to reduce their use of glucocorticoids,” Koreth says.  “These findings may have implications for a variety of diseases resulting from immune system imbalances.  This approach deserves further study in larger numbers of GVHD patients, as well as in other autoimmune diseases and solid organ transplants.”The senior author of the study is Harvard Medical School Professor of Medicine Robert Soiffer of Dana-Farber.The study was funded by the Dana-Farber Dunkin’ Donuts Rising Star program, the American Society of Blood and Marrow Transplantation, the National Institutes of Health, the Pasquarello Research Fund, and the Jock and Bunny Adams Research and Education Endowment.last_img read more


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first_imgToday marks the beginning of International Education Week, a nation-wide initiative established to promote international exchange of customs and cultures, McKenna Pencak, assistant director of communications and outreach for International Student Services and Activities (ISSA), said. Pencak said the week will be celebrated on campus through Nov. 17. “International Education Week is a national event coordinated by the US Department of State and the US Department of Education to celebrate and promote international education and global exchange between the United States and other countries,” Pencak said.  She said ISSA sponsors International Education Week at Notre Dame every year. “This year, there are thirty-five events going on over the course of the week,” Pencak said. “There’s a wide array of events ranging from theater performances and lectures to food tastings and book signings.” The week’s signature event is the International Taste of South Bend, which will be held on Wednesday, Nov. 13 in the LaFortune Ballroom, Pencak said. Free and open to the Notre Dame community, she said the event includes a sampling of international cuisine from 12 local ethnic restaurants, Pencak said. Pencak said this particular event has been successful in years past. “Last year, we had about 400 people attend the event,” Pencak said. “It’s always a lot of fun and a great way to spread cultural awareness and learn about restaurant offerings in the community.”  Timothy Roemer, a former U.S. Congressman and Ambassador to India, will be among the variety of guest speakers who will take part in the week’s events, Pencak said. Roemer will speak in the Mendoza College of Business Jordan Auditorium on Wednesday, Nov. 13 at 4 p.m.In addition to Roemer’s lecture, Pencak said student government is joining forces with Fostering Internationalism at Notre Dame (FIND) to host a student discussion with faculty members focusing on how students can integrate their voice into the University’s role as an international research institution.   “This event, in particular, will be great for students to participate in,” said Pencak. “FIND is a brand new organization on campus and the discussion will be a great way for students to get involved in the conversation about internationalism at Notre Dame.” The Brazilian Club, the Irish Club, the Muslim Students Association, the Asian American Association and the Indian Association of Notre Dame are among the student groups that will be hosting events on campus in celebration of international education week, said Pencak. “There’s a variety of events for a variety of different people. That’s the great part about the schedule this year,” Pencak said. International Education week is a wonderful celebration of different countries and cultures and a great way to learn about Notre Dame’s initiatives and programs throughout the world.” For a complete listing of the events, visit issa.nd.edu Contact Cristina Sanchez at [email protected]last_img read more


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first_imgWNYNewsNow Stock Image.App users, tap here to watch videoJAMESTOWN – Jamestown Mayor Eddie Sundquist says his administration is working with the company NextRequest to digitalize FOIL requests and responses.Sundquist’s comments came during this week’s City Council Work Session. The Mayor says the City has received 150 FOIL requests in 2020 as of meeting time, an increase which he says is partially because of the change in laws regarding the release of police discipline records.Jamestown City Clerk Jennifer Williams says the utilization of NextRequest will simplify the process for the City. “The FOIL process is very antiquated in our office,” Williams said. “This will free up our time…..and should really streamline the process.”Williams says anyone who submits a request will instantly receive a response stating the City received the request, and the City will receive a message saying a request was submitted. From there, the official in charge of the department that the request involves can respond with the records if they’re releasable.Williams says that various “sensitive” matters, such as requests for police discipline records, are also forwarded to Corporation Counsel, Elliot Raimondo, for review to determine whether or not the request can be met.The service will be free to the City, according to Sundquist.The Mayor says anyone who is dissatisfied with the FOIL response can file an appeal with his office.Share:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to email this to a friend (Opens in new window)last_img read more


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first_imgA popular state park is coping with the collapse of a retaining wall and portions of the Blue Ridge Parkway are closed after a deluge of heavy rainfall swept through western North Carolina on Monday, October 23.A retaining wall at Chimney Rock State Park, located about 25 miles southeast of Asheville in Rutherford County, collapsed after the area received 3.5 to 5 inches of rainfall over the span of several hours.Photo Courtesy Chimney Rock State ParkAccording to the Asheville Citizen Times, crews are actively working to clear the debris, and the park will be closed until further notice.The Rumbling Bald Access, popular with climbers, hikers and mountain bikers, was not affected and will remain open.The Blue Ridge Parkway is also closed, from mile marker 402.7 south of the N.C. 191/Brevard Road entrance to Milepost 408.4, due to a substantial washout near the Little Pisgah Ridge Tunnel at milemarker 407.Motorists, cyclist, and hikers are all being asked to avoid this area while park engineers assess the damage and monitor the site for additional damages.The Pisgah Inn and nearby campground remain open but are only accessible via 276.Multiple western North Carolina towns, including Boone and Asheville, experienced significant flooding as well.For updates regarding closures of the Blue Ridge Parkway, check out this real-time road map, and stay up to date with the status of Chimney Rock State Park by following them on Facebook.last_img read more


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first_imgSurinamese port officials forwarded information about the suspicious vessel to port officials in Guyana, who stopped the ship, questioned the crew and found the cocaine. Airmen from the U.S. 12th Air Force recently spent four weeks training members of the Chilean Air Force maintenance procedures for F-16 Fighting Falcons and instructed them in the use of night vision goggles. Collaboration between Guyanese and Surinamese port officials led to the seizure of more than 120 kilograms of cocaine from a ship that was expected to leave Guyana for Europe, Kurshid Sattaur, commissioner of the Guyana Revenue Authority, said on January 6. “It was really rewarding to work with them, but the partnership that we’ve developed with them has been very instrumental,” he said in a prepared statement. “Sometimes it’s not about the assistance that you provide, but what you can learn from the individuals you’re assisting, and during this trip I’ve learned a lot from the Chilean Air Force.” Master Sergeant Jeremy Jacobs, a 12th Air Force Tactical Aircraft Manager who led the training session, said the experience was extremely positive. “It was really rewarding to work with them, but the partnership that we’ve developed with them has been very instrumental,” he said in a prepared statement. “Sometimes it’s not about the assistance that you provide, but what you can learn from the individuals you’re assisting, and during this trip I’ve learned a lot from the Chilean Air Force.” Jacobs’ team worked with members of the Chilean Air Force at several bases. Collaboration between Guyanese and Surinamese port officials led to the seizure of more than 120 kilograms of cocaine from a ship that was expected to leave Guyana for Europe, Kurshid Sattaur, commissioner of the Guyana Revenue Authority, said on January 6. The 12th Air Force has spent the past 15 months in the cities of Iquique and Antofagasta working with the Chilean Air Force as part of the U.S. Southern Command’s (SOUTHCOM) goal of bolstering international cooperation through sustained engagement. Guyana and Suriname work together to make large drug seizure Port officials found the cocaine, which has a street value of about $10 million, on January 5 while searching the ship MV Delta Diedre. The vessel was registered in Cyprus and scheduled to make stops in Spain, the Netherlands and Belgium. The 12th Air Force has spent the past 15 months in the cities of Iquique and Antofagasta working with the Chilean Air Force as part of the U.S. Southern Command’s (SOUTHCOM) goal of bolstering international cooperation through sustained engagement. Surinamese port officials forwarded information about the suspicious vessel to port officials in Guyana, who stopped the ship, questioned the crew and found the cocaine. Master Sergeant Jeremy Jacobs, a 12th Air Force Tactical Aircraft Manager who led the training session, said the experience was extremely positive. “This experience has been both useful and important for both sides and has brought us closer together for the overall goal of success,” Chilean Air Force Staff Sergeant Andrés Bahamondes-Velásquez said. The 12th Air Force works in cooperation with Armed Forces in Central America, South America and the Caribbean to fight drug trafficking and improve security. “Working with the members from the United States Air Force has been amazing,” Chilean Air Force Senior Airman Pedro Aguilera, a Life Support Technician, said in a prepared statement. “Their knowledge of the different systems is great, but I think the part that amazed me was when I was able to actually assist them and showed them a few different ways to do things that make the different pieces of the equipment last longer and make common tasks more efficient.” Guyana and Suriname work together to make large drug seizure By Dialogo January 12, 2015 Jacobs’ team worked with members of the Chilean Air Force at several bases. “This experience has been both useful and important for both sides and has brought us closer together for the overall goal of success,” Chilean Air Force Staff Sergeant Andrés Bahamondes-Velásquez said. Port officials found the cocaine, which has a street value of about $10 million, on January 5 while searching the ship MV Delta Diedre. The vessel was registered in Cyprus and scheduled to make stops in Spain, the Netherlands and Belgium. “Working with the members from the United States Air Force has been amazing,” Chilean Air Force Senior Airman Pedro Aguilera, a Life Support Technician, said in a prepared statement. “Their knowledge of the different systems is great, but I think the part that amazed me was when I was able to actually assist them and showed them a few different ways to do things that make the different pieces of the equipment last longer and make common tasks more efficient.” “It was the joint intelligence that generated this trap,” Sattaur said. He didn’t immediately disclose who is believed to have owned the cocaine or if any arrests were made in connection with the seizure. The 12th Air Force works in cooperation with Armed Forces in Central America, South America and the Caribbean to fight drug trafficking and improve security. “It was the joint intelligence that generated this trap,” Sattaur said. He didn’t immediately disclose who is believed to have owned the cocaine or if any arrests were made in connection with the seizure. Airmen from the U.S. 12th Air Force recently spent four weeks training members of the Chilean Air Force maintenance procedures for F-16 Fighting Falcons and instructed them in the use of night vision goggles. last_img read more


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first_img 93SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr,John Pettit John Pettit is the Managing Editor for CUInsight.com. John manages the content on the site, including current news, editorial, press releases, jobs and events. He keeps the credit union … Web: www.cuinsight.com Details 1. Go campingCamping can be a fun time with friends and family and it’s also a lot cheaper than staying in a hotel or a resort. Take advantage of the weather before the cooler temperatures arrive. And if you can make it to the mountains, you may get a little relief from the heat that’s still hanging around.2. Find an alternative place to stayPlanning on going to the beach? Instead of paying those expensive resort prices, try finding a fully furnished place on Airbnb. Usually you can find a good location and home comforts that you wouldn’t get in a hotel. It’s nice to not have to leave your room to get ice or a cold drink.3. Don’t be afraid to cookOne of the biggest expenses you have when on vacation is food. If you’re staying somewhere with a full kitchen, make the grocery store your first stop upon arrival. By cooking breakfast and lunch, you can save money to spend on nice dinners at local hot spots. Plus, who doesn’t love breakfast? You can eat like a king for next to nothing.4. Don’t pack unnecessary personal itemsMost hotels provide essential toiletries like soap, shampoo and conditioner, as well as other things like an iron. Sure, your things may be nicer, but using free stuff is never a bad idea. Plus, your suitcase will be a little bit lighter.last_img read more


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first_imgSign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York A man crashed his SUV and died in Port Jefferson Station over the weekend.Suffolk County police said the driver was heading southbound on Route 112 in a gray 2004 Ford Explorer when he lost control near Washington Avenue and flipped over in a wooded area at 4:20 a.m. Sunday.The driver, whose identity was not immediately released, was pronounced dead at the scene.Sixth Squad detectives impounded the vehicle, are continuing the investigation and ask anyone who may have witnessed this crash to call them at 631-854-8652.last_img


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