Early spotting of Alzheimer’s is research goal

Tag: 苏州哪里有桑拿会所

first_imgFor a perfectly healthy woman, Dianne Kerley has had quite a few medical tests in recent years: MRI and PET scans of her brain, two spinal taps and hours of memory and thinking tests. Kerley, 52, has spent much of her life in the shadow of an illness that gradually destroys memory, personality and the ability to think, speak, and live independently. Her mother, grandmother and a maternal great-aunt all developed Alzheimer’s disease. Her mother, 78, is in a nursing home in the advanced stages of dementia, helpless and barely responsive. “She’s in her own private purgatory,” Kerley said. Kerley is part of an ambitious new scientific effort to find ways to detect Alzheimer’s disease at the earliest possible moment. Although the disease may seem like a calamity that strikes suddenly in old age, scientists now think it begins long before the mind fails. “PIB is about the future of where Alzheimer’s disease needs to be,” said Dr. William E. Klunk, a co-discoverer of the dye at the Alzheimer’s research center at the University of Pittsburgh. “PIB is being used today to help determine whether drugs that are meant to prevent or remove amyloid from the brain are working, so we can find drugs that prevent the underlying pathology of the disease.” Though PIB is experimental now, studies began in November that are intended to lead to government approval for wider use. Currently, for the most common form of Alzheimer’s disease, which occurs after age 65, there is no proven means of early detection, no definitive genetic test. But PIB tests might be ready before new treatments emerge, making it possible to predict who will develop Alzheimer’s – without being able to help. Researchers are also using MRI scans to look for early brain changes, and testing blood and spinal fluid for amyloid and other “biomarkers” to see if they can be used to predict Alzheimer’s or find it early. Studies of families in which multiple members have dementia are helping to sort out the genetic underpinnings of the disease. Finally, experiments are under way to find out whether drugs and vaccines can remove amyloid from the brain or prevent its buildup, and whether doing so would help patients. The new drugs, unlike the ones currently available, have the potential to stop or slow the progress of the disease. At the very least, the drug studies will be the first real test of the leading theory of Alzheimer’s, which blames amyloid for setting off a chain of events that ultimately ruin the brain. Alzheimer’s was first recognized 100 years ago, and in all that time science has been completely unable to change the course of the disease. Desperate families spend more than $1 billion a year on drugs approved for Alzheimer’s that generally have only small effects, if any, on symptoms. Patients’ agitation and hallucinations often drive relatives and nursing homes to resort to additional powerful drugs approved for other diseases like schizophrenia, drugs that can deepen the oblivion and cause severe side effects like diabetes, stroke and movement disorders. Alzheimer’s is the most common cause of dementia (artery disease, Parkinson’s and other brain disorders can also lead to dementia). Five million people in the United States have Alzheimer’s, most of them over 65. It is the nation’s sixth leading cause of death by disease, killing nearly 66,000 people a year and probably contributing to many more deaths. By 2050, according to the Alzheimer’s Association, 11 million to 16 million Americans will have the disease. “Sixteen million is a future we can’t countenance,” said William H. Thies, the association’s vice president for medical and scientific relations. “It will bankrupt our health care system.” The costs are already enormous, $148 billion a year – more than three times the cost of chronic lung disease, even though Alzheimer’s kills only half as many people. To a great extent, increases in dementia are the price of progress: More and more people are living long enough to get Alzheimer’s, some because they survived heart disease, strokes or cancer. It is a cruel trade-off. The disease is by no means inevitable, but among people 85 and older, about 40 percent develop Alzheimer’s and spend their so-called golden years in a thicket of confusion, ultimately becoming incontinent, mute, bedridden or forced to use a wheelchair and completely dependent on others. “It makes people wonder whether they really want to live that long,” Klunk said. The potential market for prevention and treatment is enormous, and drug companies are eager to exploit it. If a drug could prevent Alzheimer’s or just reduce the risk, as statins like Lipitor do for heart disease, half the population over 55 would probably need to take it, Thies said. If new drugs do emerge, they will come from studies in patients who already have symptoms, Thies said. But he said the emphasis would quickly shift to treating people at risk, before symptoms set in. Many researchers doubt that even the best preventive drugs will be able to heal the brains of people who are already demented.160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set! AD Quality Auto 360p 720p 1080p Top articles1/5READ MORECoach Doc Rivers a “fan” from way back of Jazz’s Jordan Clarkson“Alzheimer’s disease may be a chronic condition in which changes begin in midlife or even earlier,” said Dr. John C. Morris, director of the Alzheimer’s Disease Research Center at Washington University in St. Louis, where Kerley volunteers for studies. Currently, the diagnosis is not made until symptoms develop, and by then it may already be too late to rescue the brain. Drugs now in use temporarily ease symptoms for some, but cannot halt the underlying disease. Many scientists believe the best hope of progress, maybe the only hope, lies in detecting the disease early and devising treatments to stop it before brain damage becomes extensive. Better still, they would like to intervene even sooner, by identifying risk factors and treating people preventively – the same strategy that has markedly lowered death rates from heart disease, stroke and some cancers. So far, Alzheimer’s has been unyielding. But research now under way may start answering major questions about when the disease begins and how best to fight it. A radioactive dye called PIB (for Pittsburgh Compound B) has made it possible to use PET scans to find deposits of amyloid, an Alzheimer’s-related protein, in the brains of live human beings. It may lead to earlier diagnosis, help doctors distinguish Alzheimer’s from other forms of dementia and let them monitor the effects of treatment. Studies with the dye have already found significant deposits in 20 percent to 25 percent of seemingly normal people over 65, suggesting that they may be on the way to Alzheimer’s, though only time will tell. last_img read more


Tag: 苏州哪里有桑拿会所

first_imgLimited access to new agricultural technologies and delays in registering these put farmers at a disadvantage to overseas producers, who already have other advantages, including government subsidies, Absa says, adding that local farmers must be helped to gain access to markets beyond South Africa’s borders. “In addition, we insist that the farmers we finance use the most up-to-date agricultural technologies,” he said. “We need to address this holistically, and the Department of Agriculture has a significant role to play in this.” 8 September 2009 “In essence, we will fund the farmer, and the farmer will pay us with agricultural production.” As a result, many farmers operated at a loss, while around three percent simply left the business, Absa says, adding that farmers have no option but to control costs, become more productive and gain access to new markets. SAinfo reporterWould you like to use this article in your publication or on your website? See: Using SAinfo material Financial assistance “But that is easier said than done,” Janovsky said. “Local farmers are already the best in the world, and they are as productive as what the natural resources in South Africa allow. “But, as it now stands, most cannot simply produce more crops on the same land or increase the rate at which their cows produce calves.” In South Africa, farmers who want to export have to do it all by themselves, Absa says, adding that export is out of reach for all but the biggest players due to huge costs and legal constraints – and this is where the country’s banks have a role to play.center_img South African farmers need to access new markets and implement the latest technology if they are to become more competitive, while banks must expand their roles and introduce new products for the sector, says banking group Absa. “The truth is, on equal terms, South African farmers can compete with any farmer in the world, but farmers are hamstrung and many will not survive,” Janovksy said. “There is enormous potential, but it is being limited by access to international markets.” New agricultural technologies Rising input costs “Increasingly we are involved in the complete production and sales chain,” Absa Agribusiness GM Ernst Janovsky said in a statement last month. “For example, Absa Agribusiness will not only provide crop finance and insurance to a farmer, but will also act as broker, buyer and seller of his produce. According to the bank, South African farmers are facing difficult times, with input costs rising by more than 30% in 2008 – instead of the usual average annual three percent rise – due to rising fuel and fertiliser costs Janovsky said this required banks to help farmers manage price and production volatility. Price volatility could be dealt with through forwards, derivatives and futures contracts, while production risk could be limited through insurance products covering adverse climate conditions, disease and parasites. According to Absa, new agricultural technologies, like drought- or disease-resistant seeds, and new planting and irrigation techniques, are critical in overcoming biological limitations to increased productivity.last_img read more


Tag: 苏州哪里有桑拿会所

first_img30 October 2009JSE-listed IT firm Dimension Data has acquired a 51% stake in Moroccan telecommunication infrastructure services company Telcom for an undisclosed sum, thus extending the company’s footprint in the region.The company, to be acquired through Dimension Data’s Middle East and Africa business, will immediately be rebranded as Dimension Data Maroc, and plans are afoot to grow the business in the local IT marketplace.“[The] acquisition of a majority stake in Telcom enhances our plans to be represented in the four corners of emerging Africa,” Dimension Data Middle East and Africa chairman Andile Ngcaba said in a statement this week.“Morocco has a relatively well-developed ICT sector, as evidenced by the high mobile and internet penetration rates. In addition, its proximity to large EU markets, and the nature of what is essentially a services-driven economy, has also contributed to a vibrant and growing sector.”The company’s entry into the Kingdom of Morocco brings the number of employees in the Dimension Data Emerging Africa territory to around 600 employees and the Dimension Data Middle East and Africa group, incorporating South Africa, to over 5 000 employees.Dimension Data’s Algerian business, which has been operating under its European operation for the past five years, will be placed under the Middle East and Africa business as part of the group’s North Africa plan.Dimension Data MarocDimension Data Maroc will initially operate out of offices in Temara – close to Rabat – and Casablanca, with plans to grow its core business, as well as introduce data centre and storage offerings in the region.According to Ngcaba, major companies such as Microsoft and Cisco have committed their support to growing market share in the region together with Dimension Data.“Dimension Data will also provide the personnel, skills, systems, and technology support to ensure the Morocco business grows effectively,” he said. “In addition, the group will contribute its sales and delivery expertise, and deep experience in public sector markets for the region’s services offerings.”A recent Interactive Data Corporation report indicates the total ICT sector size at close to US$4.8-billion growing over the next three years at 4.8% annually. Of this overall ICT market, just over $1-billion relates to IT products and services growing at 6.9% annually.“The management and our 130-strong team of employees are delighted to be part of a global organisation,” said Telcom MD Reda Meziane Belfkih. “We have built up a solid reputation in the market since it was founded in 2000, and look forward to taking the business to a new level together with Dimension Data.”SAinfo reporterWould you like to use this article in your publication or on your website? See: Using SAinfo materiallast_img read more


Tag: 苏州哪里有桑拿会所

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Tag: 苏州哪里有桑拿会所

first_imgThis morning, at the CTIA Wireless 2011 conference in Orlando, Florida, Samsung officially introduced the newest version of its Galaxy Tab, the 8.9-inch edition. For those keeping track, that means that Samsung now has three different Android tablets: the original 7-inch, the 10.1-inch announced in February at Mobile World Congress, and now this medium-sized tablet.On stage, Samsung execs touted “personal choice” and a strategy where “one size doesn’t fit all,” but is that the case? Or is this just an expensive experiment in determining which tablets consumers will actually choose, if they’re given the option to do so? Related Posts What it Takes to Build a Highly Secure FinTech … Credit: CNETBut with so many similarities between both devices, it begs the question: why choose one over the other? It almost seems like Samsung is experimenting here – throwing out a bunch of different screen size options and waiting to see which one consumers adopt. It’s a very different strategy than the tablet leader, Apple, employs. It makes one iPad, and only one iPad. And it sells.But is the iPad the ideal tablet size for everyone? Will tablet size become a personal choice issue, similar to how Android phones vary in form factor, too? Will having different screen options be a factor in your tablet choice? Let us know what you think in the comments.Image credits: Samsung, CNET sarah perez The news of the latest tablet, the 8.9-inch Galaxy Tab, was leaked online prior to today’s announcement. But Samsung did provide a little surprise this morning – it actually revealed the new device’s pricing and launch time frame, along with that of its larger sibling.The 8.9-inch Tab will retail for $469 for the 16 GB version and $569 for the 32 GB version, and will arrive sometime early this summer. Meanwhile, the larger tablet will be $499 for the 16 GB and $599 for the 32 GB version, and will arrive June 8th.Small, Medium & Large TabsThe price differential between the two tablets doesn’t represent a wide enough gap to make choosing one tablet on the other an issue of economics, nor are the tablet specs remarkably different either (beyond screen size, of course).Both will support 4G (HSPA+ up to 21 Mbps, LTE & WiMax support coming in a later version), Wi-Fi and Bluetooth. Both are powered by a 1 GHz dual-core processor. Both have the same 1280×800 HD display and 1080p video playback. Both have a 2-megapixel front-facing camera and a 3-megapixel on in back. Both will run Adobe Flash. Both feature Samsung’s new skin designed specifically or Android 3.0 tablet computers, something Samsung calls the “TouchWiz user experience.” This UI layer features a customizable, live-updating homescreen filled with widgets and a Mini Apps Tray for launching favorite programs. They also both feature Samsung’s Hubs – the portals for interacting with music, media and social content, made available through branded apps.The 8.9-inch tablet, in particular, measures 8.6mm wide, and weighs 470 g, but both tablets are thinner and light.center_img Tags:#Android#Apple#mobile#Trends Role of Mobile App Analytics In-App Engagement Why IoT Apps are Eating Device Interfaces The Rise and Rise of Mobile Payment Technologylast_img read more


Tag: 苏州哪里有桑拿会所

first_imgWhy Tech Companies Need Simpler Terms of Servic… “Donkey Kong through every difficult juicer.” – B. FolderCommodore 64 was a milestone in personal computing. For one thing, it enabled a global Donkey Konging that gave birth to the world as we know it. Now, Commodore USA, the group of folks who bought the Commodore brand, are bringing it back, but with a significantly updated engine. The original 64 had got its name from its 64 kilobytes of memory. From its debut in 1982 until the original product stopped being produced it sold as many as 17 million units. The Commodore was the market dominant PC in the mid-80s and influenced the expectations and sense of possibilities for an entire generation of computer customers and creators. The new version of this classic computer looks the same, but is run on a Linux system. It comes with an Ubuntu system but a new operating system called the Commodore OS will be mailed out as it becomes available. It can also run Windows 7. It sports a stylish mini-ITX PC motherboard with a Dual Core 525 Atom processor and Nvidia Ion2 graphics chipset and comes equipped with Wi-Fi, a DVD drive and USB portsClearly understanding that there is a bit of computing nostalgia operant in anyone likely to buy a new Commodore, the company has set up the rig to play the original games – Ghostbuster, Commando, Paperboy, Castle Wolfenstein, etc. – in all their 8-bit glory, though a built-in emulator, or via the Commodore’s own OS. An HDMI connection updates the hook-it-up-to-your-TV experience of the original.In addition to producing the Commodore, the company is rocking the sweet, sweet Amiga, though the design of that computational Lazarus seems significantly less retro.Like the original, the new Commodore 64 is priced at $595. Boss.Photos from Wikipedia and Commodore USA | other sources: New Scientist, curt hopkins Top Reasons to Go With Managed WordPress Hosting Tags:#news#web center_img A Web Developer’s New Best Friend is the AI Wai… Related Posts 8 Best WordPress Hosting Solutions on the Marketlast_img read more


Tag: 苏州哪里有桑拿会所

first_imgTwo brothers, residents of Gurugram, were arrested by the on Tuesday night for allegedly duping a resident of Delhi running a business in Noida in 2009, the police said on Wednesday.The police said that the accused, Amit and Aman Sayal, had duped the victim of more than ₹2 crore on the pretext of selling him a property, which was not even registered in their name.“They had provided the victim, Sudhir Gupta, with fake documents pertaining to the property. The victim owned a property in Sector 6 and had showed interest in an adjacent property, which the accused claimed to own,” said Manoj Kumar Pant, Station House Officer, Sector 20 police station.The police said that the victim paid the amount to the accused in instalments and was also provided with fake ownership documents. However, when the victim went to the Noida Authority to complete the registration, they found that the property was not owned by the accused.“A case had been registered in this regard and and a non-bailable warrant was issued for the accused by the district court,” said a senior police officer.The police also said that the accused had been involved in cases of fraud. About 37 cases have been identified so far against them all over India, including Hyderabad, Mumbai, Delhi, Gujarat. The police also said that whenever the victims would approach the accused and demand their money back they would get assaulted by bouncers.last_img read more