Major League Baseball fits Oakland Athletics’ Liam Hendriks to a T

Tag: 上海桑拿会所

first_imgOAKLAND — A 5-year-old Liam Hendriks, like most other Australian kids, had to decide on a summer sport to pursue.T-ball or cricket?Tradition might’ve pulled Hendriks toward cricket — a more popular sport among Australians than baseball — but there was just something a bit more logical about T-ball for a young, short-attention spanned Hendriks and his friends.“T-ball is thirty minutes long every Saturday and cricket starts turning into three hours, six hours,” Hendriks said. “And my parents …last_img


Tag: 上海桑拿会所

first_imgWatching molecular machines at work in living cells should be as fascinating as watching a city through a magnifying glass.Observing biological nanotransporters (Science Daily). What if you could watch drawbridges working on the head of a pin? Something like that, but far smaller, works inside your cells. There’s a “nanoporter” that uses ATP to transport cargo in and out of cell membranes. This system is not as simple as A-B-C, even though it has that name.“ABC transporters are fascinating biological nanomachines,” says Lars Schäfer, head of the Molecular Simulation research group [at Ruhr-University Bochum]. These proteins couple the binding and chemical cleavage of ATP molecules, the chemical energy unit of the cell, with the transport of molecules through biological membranes….“Our results show how the binding of ATP molecules induces structural changes in the transporter that are ultimately required to carry substrate molecules through the membrane,” explains Hendrik Göddeke, co-author and doctoral researcher in Lars Schäfer’s group.Study reveals the inner workings of a molecular motor that packs and unpacks DNA (Phys.org). A chromosome remodeler named INO80 is performing onstage at the Ludwig Maximilian University of Munich: on the microscope stage, that is. Researchers at LMU watched the act of “astonishing precision” as it worked on its “heavy-duty reorganizational task” of wrapping DNA around chromatin.Chromatin remodelers have an essential role as they are molecular machines: they unpick and unpack segments of the DNA by sliding nucleosome spools back and forth, replacing individual histones, freeing up the DNA for transcription, and finally compacting it again, when the job is done. Since all of this happens in a highly dynamic fashion, chromatin remodelers enable cells to react rapidly to alterations in their environment – and this holds for brewer’s yeast as well as for human cells.The clouds of spaghetti that keep DNA data safe (Science Daily). Computer systems worry about data breaches, and so do cells. The cell nucleus is like a massive library read by numerous machines. They deliver information to the cytoplasm outside the nucleus, but only certain molecules can get in or out. This article describes some of the data protection systems provided by the Nuclear Pore Complexes (NPCs), some of the most complex machine systems in cells.Molecular machines (Illustra Media)Cells can avoid “data breaches” when letting signaling proteins into their nuclei thanks to a quirky biophysical mechanism involving a blur of spaghetti-like proteins, researchers from the Rockefeller University and the Albert Einstein College of Medicine have shown. Their study appears in the March 23 issue of the Journal of Biological Chemistry….To travel through NPCs, many molecules must be attached to proteins called transport factors (TFs), which act as shuttles that the NPC recognizes. But the NPC faces a challenge: It must accurately recognize and bind to TFs to let them through without admitting unwanted traffic, but it must let them through quickly — in a matter of milliseconds — in order for the cell to be able to do its duties. Proteins known to accurately bind to specific molecules, like antibodies, normally stay stuck to their targets for periods of up to months.“How on Earth do you have the kind of specificity that we see in protein-protein interactions like antibodies, and yet have the kind of speed that we see with water off a Teflon pan?” asked Michael Rout, professor at Rockefeller University who was one of the co-lead authors of the work.The spaghetti trick involves many intrinsically-disordered proteins in the NPC, looking somewhat like strands of spaghetti, making “many quick, transient contacts between transport factors” and nuclear proteins. How can we visualize this? “I can’t think of any analogy in normal life that does what this does,” Rout said. “You’ve got this blur of (amino acids) coming on and off (the transport factor) with extraordinary speed.” Maybe security engineers could learn something from this technique.Scientists map the portal to the cell’s nucleus (Science Daily). In this second article from Rockefeller University about the NPC, Rout did find one analogy:It reminds us of a suspension bridge, in which a combination of sturdy and flexible parts produce a stress-resilient structure, says Michael P. Rout, who led the work together with Brian T. Chait.The pore complex contains 552 component proteins, called nucleoporins, and scientists hadn’t previously known how they all fit together. It took a combination of approaches to assemble a comprehensive map of these pieces.Sadly, after comparing the NPC to lesser systems designed intelligently by humans, Rout ascribes it all to evolutionary chance. “Evolution has enclosed it with a double membrane, the nuclear envelope,” the article says, going on to visualize some unobserved miracles:The pore complex first emerged when single-celled organisms — the only living things at the time — acquired special compartments containing organ-like structures, including the nucleus, which houses the cell’s genetic code.Strings of electron-carrying proteins may hold the secret to ‘electric bacteria’ (Phys.org). This article suggests that some bacteria may have the ability to transfer electrons from the inside to the outside environment, using “micro machines” that turn on the power to extract energy from the environment. “Could a unique bacterium be nature’s microscopic power plant?” asks Moh El-Naggar, scientist at USC. Isn’t it nice to know that bacteria, “wired for survival” as among the smallest organisms on earth, are “highly evolved machines”?Microbiologists, can you please please turn off the obligatory Darwinspeak and just tell us the facts of what you are looking at? You’re beginning to sound like comedians. (Visited 422 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more


Tag: 上海桑拿会所

first_imgShare Facebook Twitter Google + LinkedIn Pinterest The Ohio Federation of Soil and Water Conservation (OFSWCD) and its’ partner, USDA Natural Resources Conservation Service (NRCS) are celebrating National Volunteer Week, April 12-18. The goal of this observance is to recognize people, who through volunteering, have furthered imaginative and productive ways to better their communities. Additionally, the hope is that by calling attention to these contributions, others will be inspired to emulate these public-spirited volunteers.“For NRCS, our organization nationwide has utilized more than 25,000 volunteers, who have donated 318,500 hours valued at $7.2 million,” said Terry Cosby, NRCS State Conservationist. “For Ohio, we were recognized with the ‘Chief’s Cup,’ the highest National Earth Team Program Award presented for excellence in leadership support, innovation, training, service and achievements. As a result of our focus on the Earth Team, Ohio led the country in both number of volunteers and volunteer hours with 5,310 volunteers and 38,285 hours of volunteer service valued at a whopping $861,418!”For the OFSWCD, “volunteers” created the conservation based organization more than 70 years ago. Throughout Ohio’s 88 counties, each Soil and Water Conservation District (SWCD) is led by a locally-elected, volunteer board consisting of five supervisors. All in all, these 440 supervisors provide dedicated hours and multiple contributions to focused conservation programs and practices completed within each county making positive contributions to improving soil health, water quality and overall quality of life.“Nearly everyone has multiple claims on their time and resources. For many, it isn’t easy to find the time to be a volunteer,” said Kris Swartz, OFSWCD President and Wood County SWCD Supervisor. “National Volunteer Week is a good time to reflect on how each of us can contribute and to thank the many who have stepped up to make a positive impact on our natural resources.”For NRCS, the “Earth Team” program utilizes a volunteer workforce that is making a difference in every county in the nation. NRCS works with private landowners to improve soil quality, conserve water, improve air quality and enhance wildlife habitat. Earth Team volunteers work side-by-side with conservation professionals and are an integral part of the conservation partnership.The job of conserving our natural resources cannot be done by the government alone. Every individual can aid in reducing soil erosion, conserving our water and improving its quality, and developing pride in our country’s natural resource heritage.“Our organizations work hand-in-hand together to conserve our natural resources. Working together, our organizations are making a difference. But we cannot do this alone. We need our local constituencies to get engaged and involved in this worthy cause,” Swartz said.To learn more about volunteer efforts, please contact your county SWCD and/or NRCS office. Or contact either the OFSWCD office at 614.784.1900 or NRCS’ State Earth Team Coordinator Dianne Johnson at 614.255.2463, www.oh.nrcs.usda.gov.last_img read more


Tag: 上海桑拿会所

first_imgI had an interaction with a large, very well known company this week. During this interaction, it was very clear that the person I was working with had no idea what they were doing, even before I asked for something that was a little challenging for her to deliver. She put me on hold five or six times, and the total interaction took almost an hour. But she did her very best, and she was very polite.The large, well known company then sent me a survey. The first question asked: “I would hire the representative I spoke with if I owned a customer service company.” I was asked to choose a rating from 0 (strongly disagree) to 10 (strongly agree).I am always unhappy giving up an hour of my life to handle an issue that should be easily resolved in a few minutes. But this customer service representative wasn’t to blame. The process was to blame.Training: It was clear the customer service person hadn’t been through any serious training. She didn’t have any idea how to respond to my request. She had to put me on hold because she had to go to her supervisor for help.I have no idea how much training she had, but my hallucination is that she was put on the phones because they needed help, not because she was well trained and ready. The hiring, training, and onboarding process are broken, not the customer service person.Hold Time: I was on hold a long time. During the time, the customer service person waited for her supervisor to give her direction. The time she waited for direction was the time I waited for an answer. I am certain the supervisor had good intentions, and I imagine he was dealing with a long line of customer service people waiting for answers.The process of providing the customer service person with help is broken. It’s broken for the customer service person, and it’s broken for the supervisor. That means it’s broken for the customer.Broken Survey: The survey is broken, too. The first question asks me whether I would hire the customer service person if I owned a customer service company. It sounds clever. I am sure the person who designed the question believes that the single greatest factor as to my satisfaction during my call is the customer service person. They may even believe that that person is empowered to help me. But the person wasn’t empowered.A better question would be “I would utilize the same process used if I owned a customer service company.”It’s easy to blame people. It’s easier than providing them with the tools, the training, the technology, the leadership, and the process they need to succeed. Assume people have good intentions and they are constrained by process. Don’t assume the process is good and you are constrained by people.QuestionsWhen people struggle, is it always the person’s fault?How does process constrain people instead of empowering them?How do you build a process that gives people the flexibility to act on behalf of the customer?What do you do to prepare people in a way that allows you to trust that they’ll make the right decision?last_img read more


Tag: 上海桑拿会所

first_imgThe Allahabad High Court on Friday directed the Uttar Pradesh government to start issuing fresh licences and no-objection certificates (NOCs) to meat traders in the State while also renewing existing licences. The court also rejected the State’s contention that ensuring the functioning and modernisation of slaughterhouses was not its responsibility and said the responsibility for constructing slaughterhouses lay with the local municipal corporations. It also said the State could not prevent people from eating meat.Order on PIL pleasA Lucknow Division Bench of Justices A.P Shahi and Sanjai Harkauli passed the interim order while hearing a bunch of 27 PIL petitions filed against the blanket shutting down of slaughterhouses and meat shops in the State after the BJP came to power in March.The court also directed the State to file its reply by July 17, the next date of hearing, and apprise it of the steps taken to find a solution to the issue of slaughterhouses and meat shops. The court said it was giving the State “ample time” to “gear up its machinery for taking positive action in the matter.”The court directed the concerned departments of the State and local bodies to renew the licenses of slaughterhouses and also issue licences based on prescribed norms. The local bodies will obliged to consider and grant No Objection Certificates as and where required under the 2011 Regulations, it said.Allow lawful activity“The inaction of the State Government in the past should not be a shield for imposing a state of almost prohibition. To provide an immediate check on unlawful activity should be simultaneous with facilitating the carrying of lawful activity, particularly that relating to food, food habits and vending thereof that is undisputedly connected with the right to life and livelihood,” the court said it its order.The court also directed the State to circulate the order among all Divisional Commissioners and District Magistrates in the State as well as local bodies so that they can provide all material to the State for implementation of the policy and removal of all obstacles.Soon after coming to power, the Yogi Adityanath government had directed administrative and police authorities to shut down or seal slaughterhouses in the State which according to it were running unlawfully or were unregistered. However, with the abattoirs, the State also shut down meat shops, throwing thousands of livelihoods into crisis. Those involved in the trade had argued that the action was arbitrary and violated their right to livelihood.The State had contended that it was under no obligation to construct slaughter houses or make provisions for them and was merely acting against illegal setups in accordance with the norms of the National Green Tribunal (NGT). V. K Singh, counsel for the meat traders, said the court’s order was a clear “rejection” of the State’s stand.last_img read more